Key Publications for ME/CFS & Long Covid

Guidelines | Muscle/Exercise | Neurological | Vascular | Immunological | Metabolic | Coagulation | Amyloid | Patient Safety

Guidelines / Overview

A Long COVID Definition: A Chronic, Systemic Disease State with Profound Consequences

Link (2024, National Academies)

Myalgic encephalomyelitis or encephalopathy/chronic fatigue syndrome: diagnosis and management

Link (2021, NICE)

Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness

Link | PDF (2015, The National Academies Press)

Long COVID: major findings, mechanisms and recommendations

Link | PDF (2023, Nature Reviews Microbiology)

Long Covid in Aotearoa NZ: Risk assessment and preventive action urgently needed

Link | PDF (2024, Public Health Communications Centre)

Characterizing Long COVID in Children and Adolescents

NICE guideline on ME/CFS: robust advice based on a thorough review of the evidence

Muscle / Exercise

The metabolic and physiologic impairments underlying long COVID associated exercise intolerance

Link | PDF (2024, Pulmonary Circulation)

Muscle abnormalities worsen after post-exertional malaise in long COVID

Link | PDF (2024, Nature Communications)

Dysregulation of extracellular vesicle protein cargo in female myalgic encephalomyelitis/chronic fatigue syndrome cases and sedentary controls in response to maximal exercise

Link | PDF (2024, Journal of Extracellular Vesicles)

Differential Cardiopulmonary Hemodynamic Phenotypes in PASC Related Exercise Intolerance

Link | PDF (2023, ERJ Open Research)

Post-COVID exercise intolerance is associated with capillary alterations and immune dysregulations in skeletal muscles

Unexplained exertional intolerance associated with impaired systemic oxygen extraction

Inability of myalgic encephalomyelitis/chronic fatigue syndrome patients to reproduce VO2peak indicates functional impairment

Neurological

Blood-brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment

Link | PDF (2024, Nature Neuroscience)

Worsening Symptoms Is Associated with Larger Cerebral Blood Flow Abnormalities during Tilt-Testing in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome ME/CFS

Link | PDF (2023, Medicina)

Long COVID Is Not a Functional Neurologic Disorder

Link | PDF (2024, Journal of Personalized Medicine)

Vascular / Endothelium

Reduced Stroke Volume and Brain Perfusion Drive Postural Hyperventilation in Postural Orthostatic Tachycardia Syndrome

Link | PDF (2024, JACC: Basic to Translational Science)

CCL2-mediated endothelial injury drives cardiac dysfunction in long COVID

Link | PDF (2024, Nature Cardiovascular Research)

Endothelial dysfunction in ME/CFS patients

Link | PDF (2023, PLOS ONE)

Cluster Analysis to Identify Long COVID Phenotypes Using 129Xe Magnetic Resonance Imaging: A Multi-centre Evaluation

Immunological

The immunology of long COVID

Link | PDF (2023, Nature Reviews Immunology)

Sex differences and immune correlates of Long Covid development, symptom persistence, and resolution

Link | PDF (2024, Science Translational Medicine)

Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2

Link | PDF (2024, Nature Immunology)

Tissue-based T cell activation and viral RNA persist for up to 2 years after SARS-CoV-2 infection

Link | PDF (2024, Science Translational Medicine)

Immunometabolic changes and potential biomarkers in CFS peripheral immune cells revealed by single-cell RNA sequencing

Link | PDF (2024, Journal of Translational Medicine)

Distinguishing features of Long COVID identified through immune profiling

Link | PDF (2023, Nature)

Divergent adaptive immune responses define two types of long COVID

Link | PDF (2023, Frontiers in Immunology)

Stress-Induced Transcriptomic Changes in Females with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Reveal Disrupted Immune Signatures

Link | PDF (2023, International Journal of Molecular Sciences)

SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 PASC

Association of vascular netosis with COVID-19 severity in asymptomatic and symptomatic patients

Epigenetic memory of coronavirus infection in innate immune cells and their progenitors

Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19

Metabolic

WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome

Link | PDF (2023, PNAS)

Urine Metabolomics Exposes Anomalous Recovery after Maximal Exertion in Female ME/CFS Patients

Link | PDF (2023, International Journal of Molecular Sciences)

Plasma metabolomics reveals disrupted response and recovery following maximal exercise in myalgic encephalomyelitis/chronic fatigue syndrome

Link | PDF (2023, JCI Insight)

Altered Fatty Acid Oxidation in Lymphocyte Populations of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Link | PDF (2023, International Journal of Molecular Sciences)

A map of metabolic phenotypes in patients with myalgic encephalomyelitis/chronic fatigue syndrome

Link | PDF (2021, JCI Insight)

An Isolated Complex V Inefficiency and Dysregulated Mitochondrial Function in Immortalized Lymphocytes from ME/CFS Patients

Link | PDF (2020, International Journal of Molecular Sciences)

SARS-CoV-2 Mitochondrial Metabolic and Epigenomic Reprogramming in COVID-19

Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts

Coagulation

Fibrin drives thromboinflammation and neuropathology in COVID-19

Link | PDF (2024, Nature)

Dysregulated platelet function in patients with postacute sequelae of COVID-19

Link | PDF (2024, Vascular Medicine)

Analysis of thrombogenicity under flow reveals new insights into the prothrombotic state of patients with post-COVID syndrome

Link | PDF (2022, Journal of Thrombosis and Haemostasis)

Data-independent LC-MS/MS analysis of ME/CFS plasma reveals a dysregulated coagulation system, endothelial dysfunction, downregulation of complement machinery

Link | PDF (2024, Cardiovascular Diabetology)

Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 PASC is accompanied by increased levels of antiplasmin

Amyloid

Cell invasive amyloid assemblies from SARS-CoV-2 peptides can form multiple polymorphs with varying neurotoxicity

Link | PDF (2024, Nanoscale)

Neurotoxic amyloidogenic peptides in the proteome of SARS-COV2: potential implications for neurological symptoms in COVID-19

Link | PDF (2022, Nature Communications)

Proteomic Evidence for Amyloidogenic Cross-Seeding in Fibrinaloid Microclots

Link | PDF (2024, International Journal of Molecular Sciences)

Amyloidogenesis of SARS-CoV-2 Spike Protein

Link | PDF (2022, Journal of the American Chemical Society)

Patient Safety

Management of Nutritional Failure in People with Severe ME/CFS: Review of the Case for Supplementing NICE Guideline NG206

Link | PDF (2024, Qeios)

Life-Threatening Malnutrition in Very Severe ME/CFS

Link | PDF (2021, Healthcare)

Maeve Boothby O'Neill: Prevention of Future Deaths Report

Link | PDF (2024, Courts and Tribunals Judiciary)

Caring for the Patient with Severe or Very Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Link | PDF (2021, Healthcare)

Graded exercise therapy for myalgic encephalomyelitis/chronic fatigue syndrome is not effective and unsafe. Re-analysis of a Cochrane review

Rethinking the treatment of chronic fatigue syndrome-a reanalysis and evaluation of findings from a recent major trial of graded exercise and CBT

The biological challenge of myalgic encephalomyelitis/chronic fatigue syndrome: a solvable problem

Last updated 17/11/24